植物血凝素在獸醫(yī)臨床上的研究應(yīng)用

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<TD id=content9 vAlign=center><STRONG style="FONT-SIZE: 14px">植物血凝素在獸醫(yī)臨床上的研究應(yīng)用　<IMG src="http://blog.35941.com/images/jhinfo.gif"></STRONG></TD></TR>
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<DIV align=right><SPAN class=textbox-label>[ 2008-8-13 22:42:00 | By: <SPAN class=style3>陳中</SPAN> ]</SPAN></DIV></TD></TR></TBODY></TABLE>
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<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">植物血凝素是一種從紅蕓豆中提取的有絲分裂原，作為一種低聚糖與蛋白質(zhì)的復(fù)合物，植物血凝素有促進(jìn)淋巴細(xì)胞有絲分裂、激活免疫細(xì)胞</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">———</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">淋巴細(xì)胞的作用。據(jù)美國(guó)《科學(xué)》雜志報(bào)道，機(jī)體免疫系統(tǒng)通過(guò)識(shí)別植物血凝素而識(shí)別病毒，并產(chǎn)生相應(yīng)的抗體和其他免疫反應(yīng)，以從體內(nèi)清除病毒。植物血凝素與黃芪多糖等多種中草藥聯(lián)用具有增效作用</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">,</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">與部分抗生素聯(lián)用具有相加作用。因其強(qiáng)大的增強(qiáng)機(jī)體非特異性免疫力的作用以及強(qiáng)效的抗病毒作用，植物血凝素在獸藥中的應(yīng)用也日益廣泛。本文對(duì)植物血凝素的抗病毒機(jī)理、增強(qiáng)免疫作用機(jī)理及其在獸藥中的研究應(yīng)用現(xiàn)狀及應(yīng)用前景做一敘述，希望能對(duì)相關(guān)藥物的研究開(kāi)發(fā)起到一定的促進(jìn)作用。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">抗病毒機(jī)理</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">植物血凝素高效廣譜的抗病毒作用，源于其能特異性的阻斷病毒與宿主細(xì)胞的結(jié)合，即病毒進(jìn)入宿主機(jī)體后，病毒黏附蛋白</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">(VAP)</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">首先與宿主靶細(xì)胞膜特異受體結(jié)合，被吸附到宿主敏感細(xì)胞上，然后通過(guò)膜融合等方式侵入細(xì)胞中，完成脫囊膜或脫殼并進(jìn)行復(fù)制、轉(zhuǎn)錄及裝配等增殖過(guò)程。植物血凝素既可以特異性與病毒黏附結(jié)合，也可以與靶細(xì)胞上的特異病毒受體結(jié)合，從而阻斷病毒與細(xì)胞的黏附，使病毒無(wú)法進(jìn)入細(xì)胞</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">,</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">以達(dá)到抗病毒抗感染的目的。同時(shí)，機(jī)體免疫系統(tǒng)通過(guò)識(shí)別植物血凝素而識(shí)別病毒</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">,</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">并產(chǎn)生相應(yīng)的抗體和其他免疫反應(yīng)</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">,</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">以從體內(nèi)清除病毒。此外植物血凝素刺激</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">T</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">淋巴細(xì)胞增殖分化，產(chǎn)生大量效應(yīng)</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">T</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">細(xì)胞和細(xì)胞毒</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">T</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">細(xì)胞，效應(yīng)</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">T</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">細(xì)胞分泌產(chǎn)生大量細(xì)胞因子（如干擾素等）殺傷病毒，細(xì)胞毒</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">T</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">細(xì)胞可直接殺傷病毒。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">免疫增強(qiáng)作用機(jī)理</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">植物血凝素能提高骨髓造血機(jī)能，促進(jìn)機(jī)體白細(xì)胞及多核白細(xì)胞明顯增加，提高機(jī)體細(xì)胞誘生干擾素的功能，增加機(jī)體免疫力，促進(jìn)抗體形成，增強(qiáng)機(jī)體對(duì)病原微生物的吞噬作用，抵抗因病毒感染造成的動(dòng)物機(jī)體免疫抑制。</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">植物血凝素的研究應(yīng)用</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">產(chǎn)品定位</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">1.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">植物血凝素主要用于激活免疫細(xì)胞</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">———</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">淋巴細(xì)胞，是一種干擾素誘導(dǎo)劑，不僅可以刺激機(jī)體產(chǎn)生白介素</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">-2</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">和干擾素，還可以刺激機(jī)體產(chǎn)生非特異性抗體。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">2.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">作為廣譜抗病毒藥，可用于防治家禽、家畜病毒性疾病，如雞的傳染性支氣管炎、傳染性喉氣管炎、新城疫、傳染性法氏囊、雞痘；鴨的鴨瘟、鴨病毒性肝炎；豬的圓環(huán)病毒、豬傳染性胃腸炎、豬病毒性腹瀉、豬繁殖與呼吸綜合征、非典型豬瘟；犬、水貂的犬瘟熱、犬細(xì)小病毒等病毒性疾病。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">3.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">作為動(dòng)物免疫增強(qiáng)劑，可用于疾病輔助用藥或用于免疫功能受損引起的疾病，用來(lái)增強(qiáng)動(dòng)物機(jī)體免疫力，提高藥物的療效。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">特點(diǎn)</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">1.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">使用方便、廣泛，可以與許多藥物同時(shí)使用，具有協(xié)同作用或相加作用。在粉散劑等許多品種藥品中添加植物血凝素凍干粉，具有明顯提高原有產(chǎn)品療效的作用，同時(shí)不干擾原產(chǎn)品的檢測(cè)；植物血凝素?zé)o種屬特異性，可廣泛在家禽、豬、牛等動(dòng)物上使用。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">2.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">使用安全，一是使用植物血凝素后不影響機(jī)體抗體水平，可用于預(yù)防肉子雞后期常發(fā)的病毒性疾病，避免了由于加強(qiáng)免疫引起的抗體水平過(guò)高及疫苗應(yīng)激反應(yīng)；二是抗病毒譜廣、毒性小、安全范圍大。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">3.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">可以與疫苗同時(shí)使用，能起到彌補(bǔ)免疫空白期，緩減疫苗應(yīng)激反應(yīng)，增強(qiáng)免疫效果的作用。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">臨床及配方推薦</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">用于預(yù)防肉雞常發(fā)的病毒病，</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">30</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">日齡左右使用</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">1</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">次</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">~2</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">次，可預(yù)防或減輕肉雞后期病毒性疾病。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">用于預(yù)防子豬斷奶前后病毒性疾病，與強(qiáng)力霉素、泰樂(lè)菌素、頭孢類抗生素等合用，避免了子豬在斷奶后因母乳抗體的喪失而導(dǎo)致免疫力下降造成的大面積發(fā)病和死亡；配合抗病毒中藥（如金絲桃素、銀翹散等）</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">+</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">廣譜抗生素用于防治雞病毒性疾病，如非典型新城疫、傳染性法氏囊病初期、各型傳染性支氣管炎、傳染性喉氣管炎、雞痘等；配合對(duì)蛋雞生殖系統(tǒng)炎癥有效的藥物，可用于治療蛋雞不明原因引起的產(chǎn)蛋下降；配合頭孢類抗生素，每月對(duì)健康蛋雞預(yù)防一次，可有效防止蛋雞發(fā)生病毒性疾??；也可防治豬的圓環(huán)病毒病、傳染性胃腸炎、非典型豬瘟、豬繁殖與呼吸綜合征、子豬斷奶綜合征；配合法氏囊抗體</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">+</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">慶大霉素（或丁胺卡那）可用于治療急慢性法氏囊?。慌浜虾粑浪幬?，可用于防治家禽傳染性支氣管炎、傳染性喉氣管炎等病毒性呼吸道系統(tǒng)疾??；配合鴨病毒性肝炎血清或黃芪多糖可用于防治鴨病毒性肝炎；配合黃芪多糖</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">+</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">丁胺卡那，用于治療鴨瘟。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">盡管植物血凝素在獸藥中有所應(yīng)用，而且臨床報(bào)道也顯示其抗病毒作用很明顯，但關(guān)于植物血凝素體內(nèi)外抗病毒活性的實(shí)驗(yàn)室研究較少，特別是作為一種廣譜抗病毒藥物，植物血凝素對(duì)不同病毒的作用效果并不完全相同。今后研究的重點(diǎn)應(yīng)放在植物血凝素對(duì)不同病毒的作用效果研究上。由于其強(qiáng)大的免疫增強(qiáng)作用，我們還可以嘗試去開(kāi)發(fā)一種</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">“</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">超級(jí)免疫增強(qiáng)劑</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">”</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋體; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">，即對(duì)多種免疫增強(qiáng)劑進(jìn)行不同的配伍篩選。如同為干擾素誘生劑，刺五加誘生干擾素的機(jī)理與植物血凝素誘生干擾素的機(jī)理不同，兩者配伍可以增強(qiáng)對(duì)干擾素的誘生效果。此外由于植物血凝素提取工藝的復(fù)雜性決定了其生產(chǎn)成本較高，如能開(kāi)發(fā)出一種更加經(jīng)濟(jì)有效的提取工藝，必然會(huì)大大促進(jìn)植物血凝素在獸藥中的應(yīng)用。總之，隨著相關(guān)研究的不斷深入，植物血凝素抗病毒、增強(qiáng)免疫作用以及其他藥用潛力將會(huì)被不斷挖掘，其應(yīng)用前景將十分廣闊。</SPAN></SPAN></DIV></SPAN></TD></TR></TBODY></TABLE>

jinmingbi6

現(xiàn)在已普遍接受，不過(guò)價(jià)格好像不便宜啊。